DNA motif elucidation using belief propagation
Identifieur interne : 002024 ( Main/Exploration ); précédent : 002023; suivant : 002025DNA motif elucidation using belief propagation
Auteurs : Ka-Chun Wong [Canada] ; Tak-Ming Chan [États-Unis] ; Chengbin Peng ; Yue Li [Canada] ; Zhaolei Zhang [Canada]Source :
- Nucleic Acids Research [ 0305-1048 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : DNA.
- chemical , metabolism : DNA, DNA-Binding Proteins, Transcription Factors.
- methods : Sequence Analysis, DNA.
- Algorithms, Animals, Binding Sites, Markov Chains, Mice, Nucleotide Motifs, Protein Array Analysis.
Abstract
Protein-binding microarray (PBM) is a high-throughout platform that can measure the DNA-binding preference of a protein in a comprehensive and unbiased manner. A typical PBM experiment can measure binding signal intensities of a protein to all the possible DNA k-mers (k = 8 ∼10); such comprehensive binding affinity data usually need to be reduced and represented as motif models before they can be further analyzed and applied. Since proteins can often bind to DNA in multiple modes, one of the major challenges is to decompose the comprehensive affinity data into multimodal motif representations. Here, we describe a new algorithm that uses Hidden Markov Models (HMMs) and can derive precise and multimodal motifs using belief propagations. We describe an HMM-based approach using belief propagations (kmerHMM), which accepts and preprocesses PBM probe raw data into median-binding intensities of individual k-mers. The k-mers are ranked and aligned for training an HMM as the underlying motif representation. Multiple motifs are then extracted from the HMM using belief propagations. Comparisons of kmerHMM with other leading methods on several data sets demonstrated its effectiveness and uniqueness. Especially, it achieved the best performance on more than half of the data sets. In addition, the multiple binding modes derived by kmerHMM are biologically meaningful and will be useful in interpreting other genome-wide data such as those generated from ChIP-seq. The executables and source codes are available at the authors’ websites: e.g.
Url:
DOI: 10.1093/nar/gkt574
PubMed: 23814189
PubMed Central: 3763557
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000F52
- to stream Pmc, to step Curation: 000F52
- to stream Pmc, to step Checkpoint: 001242
- to stream PubMed, to step Corpus: 001C69
- to stream PubMed, to step Curation: 001C69
- to stream PubMed, to step Checkpoint: 001B73
- to stream Ncbi, to step Merge: 000A70
- to stream Ncbi, to step Curation: 000A70
- to stream Ncbi, to step Checkpoint: 000A70
- to stream Main, to step Merge: 002045
- to stream Main, to step Curation: 002024
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">DNA motif elucidation using belief propagation</title><author><name sortKey="Wong, Ka Chun" sort="Wong, Ka Chun" uniqKey="Wong K" first="Ka-Chun" last="Wong">Ka-Chun Wong</name><affiliation wicri:level="4"><nlm:aff id="gkt574-AFF1">Department of Computer Science, University of Toronto, Toronto, Ontario, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Computer Science, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="gkt574-AFF1">Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Chan, Tak Ming" sort="Chan, Tak Ming" uniqKey="Chan T" first="Tak-Ming" last="Chan">Tak-Ming Chan</name><affiliation wicri:level="2"><nlm:aff id="gkt574-AFF1">Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Peng, Chengbin" sort="Peng, Chengbin" uniqKey="Peng C" first="Chengbin" last="Peng">Chengbin Peng</name><affiliation><nlm:aff id="gkt574-AFF1">Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Jeddah, KSA,</nlm:aff><wicri:noCountry code="subfield">KSA</wicri:noCountry></affiliation></author><author><name sortKey="Li, Yue" sort="Li, Yue" uniqKey="Li Y" first="Yue" last="Li">Yue Li</name><affiliation wicri:level="4"><nlm:aff id="gkt574-AFF1">Department of Computer Science, University of Toronto, Toronto, Ontario, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Computer Science, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="gkt574-AFF1">Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Zhang, Zhaolei" sort="Zhang, Zhaolei" uniqKey="Zhang Z" first="Zhaolei" last="Zhang">Zhaolei Zhang</name><affiliation wicri:level="4"><nlm:aff id="gkt574-AFF1">Department of Computer Science, University of Toronto, Toronto, Ontario, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Computer Science, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="gkt574-AFF1">Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff wicri:cut=" and" id="gkt574-AFF1">Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="gkt574-AFF1">Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23814189</idno><idno type="pmc">3763557</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763557</idno><idno type="RBID">PMC:3763557</idno><idno type="doi">10.1093/nar/gkt574</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000F52</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F52</idno><idno type="wicri:Area/Pmc/Curation">000F52</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000F52</idno><idno type="wicri:Area/Pmc/Checkpoint">001242</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001242</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:23814189</idno><idno type="wicri:Area/PubMed/Corpus">001C69</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C69</idno><idno type="wicri:Area/PubMed/Curation">001C69</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001C69</idno><idno type="wicri:Area/PubMed/Checkpoint">001B73</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001B73</idno><idno type="wicri:Area/Ncbi/Merge">000A70</idno><idno type="wicri:Area/Ncbi/Curation">000A70</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A70</idno><idno type="wicri:doubleKey">0305-1048:2013:Wong K:dna:motif:elucidation</idno><idno type="wicri:Area/Main/Merge">002045</idno><idno type="wicri:Area/Main/Curation">002024</idno><idno type="wicri:Area/Main/Exploration">002024</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">DNA motif elucidation using belief propagation</title><author><name sortKey="Wong, Ka Chun" sort="Wong, Ka Chun" uniqKey="Wong K" first="Ka-Chun" last="Wong">Ka-Chun Wong</name><affiliation wicri:level="4"><nlm:aff id="gkt574-AFF1">Department of Computer Science, University of Toronto, Toronto, Ontario, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Computer Science, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="gkt574-AFF1">Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Chan, Tak Ming" sort="Chan, Tak Ming" uniqKey="Chan T" first="Tak-Ming" last="Chan">Tak-Ming Chan</name><affiliation wicri:level="2"><nlm:aff id="gkt574-AFF1">Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Peng, Chengbin" sort="Peng, Chengbin" uniqKey="Peng C" first="Chengbin" last="Peng">Chengbin Peng</name><affiliation><nlm:aff id="gkt574-AFF1">Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Jeddah, KSA,</nlm:aff><wicri:noCountry code="subfield">KSA</wicri:noCountry></affiliation></author><author><name sortKey="Li, Yue" sort="Li, Yue" uniqKey="Li Y" first="Yue" last="Li">Yue Li</name><affiliation wicri:level="4"><nlm:aff id="gkt574-AFF1">Department of Computer Science, University of Toronto, Toronto, Ontario, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Computer Science, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="gkt574-AFF1">Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Zhang, Zhaolei" sort="Zhang, Zhaolei" uniqKey="Zhang Z" first="Zhaolei" last="Zhang">Zhaolei Zhang</name><affiliation wicri:level="4"><nlm:aff id="gkt574-AFF1">Department of Computer Science, University of Toronto, Toronto, Ontario, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Computer Science, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="gkt574-AFF1">Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff wicri:cut=" and" id="gkt574-AFF1">Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="gkt574-AFF1">Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">Nucleic Acids Research</title><idno type="ISSN">0305-1048</idno><idno type="eISSN">1362-4962</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithms</term><term>Animals</term><term>Binding Sites</term><term>DNA (chemistry)</term><term>DNA (metabolism)</term><term>DNA-Binding Proteins (metabolism)</term><term>Markov Chains</term><term>Mice</term><term>Nucleotide Motifs</term><term>Protein Array Analysis</term><term>Sequence Analysis, DNA (methods)</term><term>Transcription Factors (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN ()</term><term>ADN (métabolisme)</term><term>Algorithmes</term><term>Analyse de séquence d'ADN ()</term><term>Analyse par réseau de protéines</term><term>Animaux</term><term>Chaines de Markov</term><term>Facteurs de transcription (métabolisme)</term><term>Motifs nucléotidiques</term><term>Protéines de liaison à l'ADN (métabolisme)</term><term>Sites de fixation</term><term>Souris</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>DNA</term><term>DNA-Binding Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ADN</term><term>Facteurs de transcription</term><term>Protéines de liaison à l'ADN</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Algorithms</term><term>Animals</term><term>Binding Sites</term><term>Markov Chains</term><term>Mice</term><term>Nucleotide Motifs</term><term>Protein Array Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ADN</term><term>Algorithmes</term><term>Analyse de séquence d'ADN</term><term>Analyse par réseau de protéines</term><term>Animaux</term><term>Chaines de Markov</term><term>Motifs nucléotidiques</term><term>Sites de fixation</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Protein-binding microarray (PBM) is a high-throughout platform that can measure the DNA-binding preference of a protein in a comprehensive and unbiased manner. A typical PBM experiment can measure binding signal intensities of a protein to all the possible DNA k-mers (k = 8 ∼10); such comprehensive binding affinity data usually need to be reduced and represented as motif models before they can be further analyzed and applied. Since proteins can often bind to DNA in multiple modes, one of the major challenges is to decompose the comprehensive affinity data into multimodal motif representations. Here, we describe a new algorithm that uses Hidden Markov Models (HMMs) and can derive precise and multimodal motifs using belief propagations. We describe an HMM-based approach using belief propagations (kmerHMM), which accepts and preprocesses PBM probe raw data into median-binding intensities of individual k-mers. The k-mers are ranked and aligned for training an HMM as the underlying motif representation. Multiple motifs are then extracted from the HMM using belief propagations. Comparisons of kmerHMM with other leading methods on several data sets demonstrated its effectiveness and uniqueness. Especially, it achieved the best performance on more than half of the data sets. In addition, the multiple binding modes derived by kmerHMM are biologically meaningful and will be useful in interpreting other genome-wide data such as those generated from ChIP-seq. The executables and source codes are available at the authors’ websites: e.g. <ext-link ext-link-type="uri" xlink:href="http://www.cs.toronto.edu/~wkc/kmerHMM">http://www.cs.toronto.edu/∼wkc/kmerHMM</ext-link>.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Tompa, M" uniqKey="Tompa M">M Tompa</name></author><author><name sortKey="Li, N" uniqKey="Li N">N Li</name></author><author><name sortKey="Bailey, Tl" uniqKey="Bailey T">TL Bailey</name></author><author><name sortKey="Church, Gm" uniqKey="Church G">GM Church</name></author><author><name sortKey="Moor, Bd" uniqKey="Moor B">BD Moor</name></author><author><name sortKey="Eskin, E" uniqKey="Eskin E">E Eskin</name></author><author><name sortKey="Favorov, Av" uniqKey="Favorov A">AV Favorov</name></author><author><name sortKey="Frith, Mc" uniqKey="Frith M">MC Frith</name></author><author><name sortKey="Fu, Y" uniqKey="Fu Y">Y Fu</name></author><author><name sortKey="Kent, Wj" uniqKey="Kent W">WJ Kent</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galas, Dj" uniqKey="Galas D">DJ Galas</name></author><author><name sortKey="Schmitz, A" uniqKey="Schmitz A">A Schmitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garner, Mm" uniqKey="Garner M">MM Garner</name></author><author><name sortKey="Revzin, A" uniqKey="Revzin A">A Revzin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, B" uniqKey="Ren B">B Ren</name></author><author><name sortKey="Robert, F" uniqKey="Robert F">F Robert</name></author><author><name sortKey="Wyrick, Jj" uniqKey="Wyrick J">JJ Wyrick</name></author><author><name sortKey="Aparicio, O" uniqKey="Aparicio O">O Aparicio</name></author><author><name sortKey="Jennings, Eg" uniqKey="Jennings E">EG Jennings</name></author><author><name sortKey="Simon, I" uniqKey="Simon I">I Simon</name></author><author><name sortKey="Zeitlinger, J" uniqKey="Zeitlinger J">J Zeitlinger</name></author><author><name sortKey="Schreiber, J" uniqKey="Schreiber J">J Schreiber</name></author><author><name sortKey="Hannett, N" uniqKey="Hannett N">N Hannett</name></author><author><name sortKey="Kanin, E" uniqKey="Kanin E">E Kanin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, Ds" uniqKey="Johnson D">DS Johnson</name></author><author><name sortKey="Mortazavi, A" uniqKey="Mortazavi A">A Mortazavi</name></author><author><name sortKey="Myers, Rm" uniqKey="Myers R">RM Myers</name></author><author><name sortKey="Wold, B" uniqKey="Wold B">B Wold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Xs" uniqKey="Liu X">XS Liu</name></author><author><name sortKey="Brutlag, Dl" uniqKey="Brutlag D">DL Brutlag</name></author><author><name sortKey="Liu, Js" uniqKey="Liu J">JS Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berger, Mf" uniqKey="Berger M">MF Berger</name></author><author><name sortKey="Philippakis, Aa" uniqKey="Philippakis A">AA Philippakis</name></author><author><name sortKey="Qureshi, Am" uniqKey="Qureshi A">AM Qureshi</name></author><author><name sortKey="He, Fs" uniqKey="He F">FS He</name></author><author><name sortKey="Estep, Pw" uniqKey="Estep P">PW Estep</name></author><author><name sortKey="Bulyk, Ml" uniqKey="Bulyk M">ML Bulyk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fordyce, Pm" uniqKey="Fordyce P">PM Fordyce</name></author><author><name sortKey="Gerber, D" uniqKey="Gerber D">D Gerber</name></author><author><name sortKey="Tran, D" uniqKey="Tran D">D Tran</name></author><author><name sortKey="Zheng, J" uniqKey="Zheng J">J Zheng</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Derisi, Jl" uniqKey="Derisi J">JL DeRisi</name></author><author><name sortKey="Quake, Sr" uniqKey="Quake S">SR Quake</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu, S" uniqKey="Hu S">S Hu</name></author><author><name sortKey="Xie, Z" uniqKey="Xie Z">Z Xie</name></author><author><name sortKey="Onishi, A" uniqKey="Onishi A">A Onishi</name></author><author><name sortKey="Yu, X" uniqKey="Yu X">X Yu</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author><author><name sortKey="Lin, J" uniqKey="Lin J">J Lin</name></author><author><name sortKey="Rho, Hs" uniqKey="Rho H">HS Rho</name></author><author><name sortKey="Woodard, C" uniqKey="Woodard C">C Woodard</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Jeong, Js" uniqKey="Jeong J">JS Jeong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, Sw" uniqKey="Ho S">SW Ho</name></author><author><name sortKey="Jona, G" uniqKey="Jona G">G Jona</name></author><author><name sortKey="Chen, Ct" uniqKey="Chen C">CT Chen</name></author><author><name sortKey="Johnston, M" uniqKey="Johnston M">M Johnston</name></author><author><name sortKey="Snyder, M" uniqKey="Snyder M">M Snyder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matys, V" uniqKey="Matys V">V Matys</name></author><author><name sortKey="Kel Margoulis, Ov" uniqKey="Kel Margoulis O">OV Kel-Margoulis</name></author><author><name sortKey="Fricke, E" uniqKey="Fricke E">E Fricke</name></author><author><name sortKey="Liebich, I" uniqKey="Liebich I">I Liebich</name></author><author><name sortKey="Land, S" uniqKey="Land S">S Land</name></author><author><name sortKey="Barre Dirrie, A" uniqKey="Barre Dirrie A">A Barre-Dirrie</name></author><author><name sortKey="Reuter, I" uniqKey="Reuter I">I Reuter</name></author><author><name sortKey="Chekmenev, D" uniqKey="Chekmenev D">D Chekmenev</name></author><author><name sortKey="Krull, M" uniqKey="Krull M">M Krull</name></author><author><name sortKey="Hornischer, K" uniqKey="Hornischer K">K Hornischer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Portales Casamar, E" uniqKey="Portales Casamar E">E Portales-Casamar</name></author><author><name sortKey="Thongjuea, S" uniqKey="Thongjuea S">S Thongjuea</name></author><author><name sortKey="Kwon, At" uniqKey="Kwon A">AT Kwon</name></author><author><name sortKey="Arenillas, D" uniqKey="Arenillas D">D Arenillas</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name></author><author><name sortKey="Valen, E" uniqKey="Valen E">E Valen</name></author><author><name sortKey="Yusuf, D" uniqKey="Yusuf D">D Yusuf</name></author><author><name sortKey="Lenhard, B" uniqKey="Lenhard B">B Lenhard</name></author><author><name sortKey="Wasserman, Ww" uniqKey="Wasserman W">WW Wasserman</name></author><author><name sortKey="Sandelin, A" uniqKey="Sandelin A">A Sandelin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bateman, A" uniqKey="Bateman A">A Bateman</name></author><author><name sortKey="Coin, L" uniqKey="Coin L">L Coin</name></author><author><name sortKey="Durbin, R" uniqKey="Durbin R">R Durbin</name></author><author><name sortKey="Finn, Rd" uniqKey="Finn R">RD Finn</name></author><author><name sortKey="Hollich, V" uniqKey="Hollich V">V Hollich</name></author><author><name sortKey="Grifrths Jones, S" uniqKey="Grifrths Jones S">S GrifRths-Jones</name></author><author><name sortKey="Khanna, A" uniqKey="Khanna A">A Khanna</name></author><author><name sortKey="Marshall, M" uniqKey="Marshall M">M Marshall</name></author><author><name sortKey="Moxon, S" uniqKey="Moxon S">S Moxon</name></author><author><name sortKey="Sonnhammer, Ell" uniqKey="Sonnhammer E">ELL Sonnhammer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robasky, K" uniqKey="Robasky K">K Robasky</name></author><author><name sortKey="Bulyk, Ml" uniqKey="Bulyk M">ML Bulyk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spivak, At" uniqKey="Spivak A">AT Spivak</name></author><author><name sortKey="Stormo, Gd" uniqKey="Stormo G">GD Stormo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pfreundt, U" uniqKey="Pfreundt U">U Pfreundt</name></author><author><name sortKey="James, Dp" uniqKey="James D">DP James</name></author><author><name sortKey="Tweedie, S" uniqKey="Tweedie S">S Tweedie</name></author><author><name sortKey="Wilson, D" uniqKey="Wilson D">D Wilson</name></author><author><name sortKey="Teichmann, Sa" uniqKey="Teichmann S">SA Teichmann</name></author><author><name sortKey="Adryan, B" uniqKey="Adryan B">B Adryan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deboer, Cg" uniqKey="Deboer C">CG deBoer</name></author><author><name sortKey="Hughes, Tr" uniqKey="Hughes T">TR Hughes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, Z" uniqKey="Xie Z">Z Xie</name></author><author><name sortKey="Hu, S" uniqKey="Hu S">S Hu</name></author><author><name sortKey="Blackshaw, S" uniqKey="Blackshaw S">S Blackshaw</name></author><author><name sortKey="Zhu, H" uniqKey="Zhu H">H Zhu</name></author><author><name sortKey="Qian, J" uniqKey="Qian J">J Qian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fulton, Dl" uniqKey="Fulton D">DL Fulton</name></author><author><name sortKey="Sundararajan, S" uniqKey="Sundararajan S">S Sundararajan</name></author><author><name sortKey="Badis, G" uniqKey="Badis G">G Badis</name></author><author><name sortKey="Hughes, Tr" uniqKey="Hughes T">TR Hughes</name></author><author><name sortKey="Wasserman, Ww" uniqKey="Wasserman W">WW Wasserman</name></author><author><name sortKey="Roach, Jc" uniqKey="Roach J">JC Roach</name></author><author><name sortKey="Sladek, R" uniqKey="Sladek R">R Sladek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luscombe, Nm" uniqKey="Luscombe N">NM Luscombe</name></author><author><name sortKey="Austin, Se" uniqKey="Austin S">SE Austin</name></author><author><name sortKey="Berman, Hm" uniqKey="Berman H">HM Berman</name></author><author><name sortKey="Thornton, Jm" uniqKey="Thornton J">JM Thornton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luscombe, Nm" uniqKey="Luscombe N">NM Luscombe</name></author><author><name sortKey="Laskowski, Ra" uniqKey="Laskowski R">RA Laskowski</name></author><author><name sortKey="Thornton, Jm" uniqKey="Thornton J">JM Thornton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krishna, Ss" uniqKey="Krishna S">SS Krishna</name></author><author><name sortKey="Majumdar, I" uniqKey="Majumdar I">I Majumdar</name></author><author><name sortKey="Grishin, Nv" uniqKey="Grishin N">NV Grishin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luscombe, Nm" uniqKey="Luscombe N">NM Luscombe</name></author><author><name sortKey="Thornton, Jm" uniqKey="Thornton J">JM Thornton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, S" uniqKey="Jones S">S Jones</name></author><author><name sortKey="Van Heyningen, P" uniqKey="Van Heyningen P">P van Heyningen</name></author><author><name sortKey="Berman, Hm" uniqKey="Berman H">HM Berman</name></author><author><name sortKey="Thornton, Jm" uniqKey="Thornton J">JM Thornton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, S" uniqKey="Jones S">S Jones</name></author><author><name sortKey="Shanahan, Hp" uniqKey="Shanahan H">HP Shanahan</name></author><author><name sortKey="Berman, Hm" uniqKey="Berman H">HM Berman</name></author><author><name sortKey="Thornton, Jm" uniqKey="Thornton J">JM Thornton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gunewardena, S" uniqKey="Gunewardena S">S Gunewardena</name></author><author><name sortKey="Jeavons, P" uniqKey="Jeavons P">P Jeavons</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sarai, A" uniqKey="Sarai A">A Sarai</name></author><author><name sortKey="Kono, H" uniqKey="Kono H">H Kono</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, Q" uniqKey="Zhou Q">Q Zhou</name></author><author><name sortKey="Liu, Js" uniqKey="Liu J">JS Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahmad, S" uniqKey="Ahmad S">S Ahmad</name></author><author><name sortKey="Gromiha, Mm" uniqKey="Gromiha M">MM Gromiha</name></author><author><name sortKey="Sarai, A" uniqKey="Sarai A">A Sarai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahmad, S" uniqKey="Ahmad S">S Ahmad</name></author><author><name sortKey="Keskin, O" uniqKey="Keskin O">O Keskin</name></author><author><name sortKey="Sarai, A" uniqKey="Sarai A">A Sarai</name></author><author><name sortKey="Nussinov, R" uniqKey="Nussinov R">R Nussinov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pham, Th" uniqKey="Pham T">TH Pham</name></author><author><name sortKey="Clemente, Jc" uniqKey="Clemente J">JC Clemente</name></author><author><name sortKey="Satou, K" uniqKey="Satou K">K Satou</name></author><author><name sortKey="Ho, Tb" uniqKey="Ho T">TB Ho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ofran, Y" uniqKey="Ofran Y">Y Ofran</name></author><author><name sortKey="Mysore, V" uniqKey="Mysore V">V Mysore</name></author><author><name sortKey="Rost, B" uniqKey="Rost B">B Rost</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Kc" uniqKey="Wong K">KC Wong</name></author><author><name sortKey="Peng, C" uniqKey="Peng C">C Peng</name></author><author><name sortKey="Wong, Mh" uniqKey="Wong M">MH Wong</name></author><author><name sortKey="Leung, Ks" uniqKey="Leung K">KS Leung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, Ks" uniqKey="Leung K">KS Leung</name></author><author><name sortKey="Wong, Kc" uniqKey="Wong K">KC Wong</name></author><author><name sortKey="Chan, Tm" uniqKey="Chan T">TM Chan</name></author><author><name sortKey="Wong, Mh" uniqKey="Wong M">MH Wong</name></author><author><name sortKey="Lee, Kh" uniqKey="Lee K">KH Lee</name></author><author><name sortKey="Lau, Ck" uniqKey="Lau C">CK Lau</name></author><author><name sortKey="Tsui, Sk" uniqKey="Tsui S">SK Tsui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Tm" uniqKey="Chan T">TM Chan</name></author><author><name sortKey="Wong, Kc" uniqKey="Wong K">KC Wong</name></author><author><name sortKey="Lee, Kh" uniqKey="Lee K">KH Lee</name></author><author><name sortKey="Wong, Mh" uniqKey="Wong M">MH Wong</name></author><author><name sortKey="Lau, Ck" uniqKey="Lau C">CK Lau</name></author><author><name sortKey="Tsui, Sk" uniqKey="Tsui S">SK Tsui</name></author><author><name sortKey="Leung, Ks" uniqKey="Leung K">KS Leung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Macisaac, Kd" uniqKey="Macisaac K">KD MacIsaac</name></author><author><name sortKey="Fraenkel, E" uniqKey="Fraenkel E">E Fraenkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kel, Ae" uniqKey="Kel A">AE Kel</name></author><author><name sortKey="Goessling, E" uniqKey="Goessling E">E Goessling</name></author><author><name sortKey="Reuter, I" uniqKey="Reuter I">I Reuter</name></author><author><name sortKey="Cheremushkin, E" uniqKey="Cheremushkin E">E Cheremushkin</name></author><author><name sortKey="Kel Margoulis, Ov" uniqKey="Kel Margoulis O">OV Kel-Margoulis</name></author><author><name sortKey="Wingender, E" uniqKey="Wingender E">E Wingender</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stormo, Gd" uniqKey="Stormo G">GD Stormo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jensen, St" uniqKey="Jensen S">ST Jensen</name></author><author><name sortKey="Liu, Xs" uniqKey="Liu X">XS Liu</name></author><author><name sortKey="Zhou, Q" uniqKey="Zhou Q">Q Zhou</name></author><author><name sortKey="Liu, Js" uniqKey="Liu J">JS Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sandve, Gk" uniqKey="Sandve G">GK Sandve</name></author><author><name sortKey="Abul, O" uniqKey="Abul O">O Abul</name></author><author><name sortKey="Walseng, V" uniqKey="Walseng V">V Walseng</name></author><author><name sortKey="Drablos, F" uniqKey="Drablos F">F Drablos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hughes, Jd" uniqKey="Hughes J">JD Hughes</name></author><author><name sortKey="Estep, Pw" uniqKey="Estep P">PW Estep</name></author><author><name sortKey="Tavazoie, S" uniqKey="Tavazoie S">S Tavazoie</name></author><author><name sortKey="Church, Gm" uniqKey="Church G">GM Church</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thijs, G" uniqKey="Thijs G">G Thijs</name></author><author><name sortKey="Lescot, M" uniqKey="Lescot M">M Lescot</name></author><author><name sortKey="Marchal, K" uniqKey="Marchal K">K Marchal</name></author><author><name sortKey="Rombauts, S" uniqKey="Rombauts S">S Rombauts</name></author><author><name sortKey="Demoor, B" uniqKey="Demoor B">B DeMoor</name></author><author><name sortKey="Rouze, P" uniqKey="Rouze P">P Rouze</name></author><author><name sortKey="Moreau, Y" uniqKey="Moreau Y">Y Moreau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ao, W" uniqKey="Ao W">W Ao</name></author><author><name sortKey="Gaudet, J" uniqKey="Gaudet J">J Gaudet</name></author><author><name sortKey="Kent, Wj" uniqKey="Kent W">WJ Kent</name></author><author><name sortKey="Muttumu, S" uniqKey="Muttumu S">S Muttumu</name></author><author><name sortKey="Mango, Se" uniqKey="Mango S">SE Mango</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bailey, Tl" uniqKey="Bailey T">TL Bailey</name></author><author><name sortKey="Elkan, C" uniqKey="Elkan C">C Elkan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Workman, Ct" uniqKey="Workman C">CT Workman</name></author><author><name sortKey="Stormo, Gd" uniqKey="Stormo G">GD Stormo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Favorov, Av" uniqKey="Favorov A">AV Favorov</name></author><author><name sortKey="Gelfand, Ms" uniqKey="Gelfand M">MS Gelfand</name></author><author><name sortKey="Gerasimova, Av" uniqKey="Gerasimova A">AV Gerasimova</name></author><author><name sortKey="Ravcheev, Da" uniqKey="Ravcheev D">DA Ravcheev</name></author><author><name sortKey="Mironov, Aa" uniqKey="Mironov A">AA Mironov</name></author><author><name sortKey="Makeev, Vj" uniqKey="Makeev V">VJ Makeev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Tm" uniqKey="Chan T">TM Chan</name></author><author><name sortKey="Leung, Ks" uniqKey="Leung K">KS Leung</name></author><author><name sortKey="Lee, Kh" uniqKey="Lee K">KH Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hertz, Gz" uniqKey="Hertz G">GZ Hertz</name></author><author><name sortKey="Stormo, Gd" uniqKey="Stormo G">GD Stormo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frith, Mc" uniqKey="Frith M">MC Frith</name></author><author><name sortKey="Hansen, U" uniqKey="Hansen U">U Hansen</name></author><author><name sortKey="Spouge, Jl" uniqKey="Spouge J">JL Spouge</name></author><author><name sortKey="Weng, Z" uniqKey="Weng Z">Z Weng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eskin, E" uniqKey="Eskin E">E Eskin</name></author><author><name sortKey="Pevzner, Pa" uniqKey="Pevzner P">PA Pevzner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Helden, J" uniqKey="Van Helden J">J van Helden</name></author><author><name sortKey="Andre, B" uniqKey="Andre B">B Andre</name></author><author><name sortKey="Collado Vides, J" uniqKey="Collado Vides J">J Collado-Vides</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gunewardena, S" uniqKey="Gunewardena S">S Gunewardena</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Regnier, M" uniqKey="Regnier M">M Régnier</name></author><author><name sortKey="Denise, A" uniqKey="Denise A">A Denise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pavesi, G" uniqKey="Pavesi G">G Pavesi</name></author><author><name sortKey="Mereghetti, P" uniqKey="Mereghetti P">P Mereghetti</name></author><author><name sortKey="Mauri, G" uniqKey="Mauri G">G Mauri</name></author><author><name sortKey="Pesole, G" uniqKey="Pesole G">G Pesole</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sinha, S" uniqKey="Sinha S">S Sinha</name></author><author><name sortKey="Tompa, M" uniqKey="Tompa M">M Tompa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Badis, G" uniqKey="Badis G">G Badis</name></author><author><name sortKey="Berger, Mf" uniqKey="Berger M">MF Berger</name></author><author><name sortKey="Philippakis, Aa" uniqKey="Philippakis A">AA Philippakis</name></author><author><name sortKey="Talukder, S" uniqKey="Talukder S">S Talukder</name></author><author><name sortKey="Gehrke, Ar" uniqKey="Gehrke A">AR Gehrke</name></author><author><name sortKey="Jaeger, Sa" uniqKey="Jaeger S">SA Jaeger</name></author><author><name sortKey="Chan, T" uniqKey="Chan T">T Chan</name></author><author><name sortKey="Metzler, G" uniqKey="Metzler G">G Metzler</name></author><author><name sortKey="Vedenko, A" uniqKey="Vedenko A">A Vedenko</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Hughes, Tr" uniqKey="Hughes T">TR Hughes</name></author><author><name sortKey="Morris, Q" uniqKey="Morris Q">Q Morris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Foat, Bc" uniqKey="Foat B">BC Foat</name></author><author><name sortKey="Houshmandi, Ss" uniqKey="Houshmandi S">SS Houshmandi</name></author><author><name sortKey="Olivas, Wm" uniqKey="Olivas W">WM Olivas</name></author><author><name sortKey="Bussemaker, Hj" uniqKey="Bussemaker H">HJ Bussemaker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanay, A" uniqKey="Tanay A">A Tanay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name></author><author><name sortKey="Stormo, Gd" uniqKey="Stormo G">GD Stormo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weirauch, Mt" uniqKey="Weirauch M">MT Weirauch</name></author><author><name sortKey="Cote, A" uniqKey="Cote A">A Cote</name></author><author><name sortKey="Norel, R" uniqKey="Norel R">R Norel</name></author><author><name sortKey="Annala, M" uniqKey="Annala M">M Annala</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name></author><author><name sortKey="Riley, Tr" uniqKey="Riley T">TR Riley</name></author><author><name sortKey="Saez Rodriguez, J" uniqKey="Saez Rodriguez J">J Saez-Rodriguez</name></author><author><name sortKey="Cokelaer, T" uniqKey="Cokelaer T">T Cokelaer</name></author><author><name sortKey="Vedenko, A" uniqKey="Vedenko A">A Vedenko</name></author><author><name sortKey="Talukder, S" uniqKey="Talukder S">S Talukder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berg, Og" uniqKey="Berg O">OG Berg</name></author><author><name sortKey="Von Hippel, Ph" uniqKey="Von Hippel P">PH von Hippel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stormo, Gd" uniqKey="Stormo G">GD Stormo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Durbin, R" uniqKey="Durbin R">R Durbin</name></author><author><name sortKey="Eddy, Sr" uniqKey="Eddy S">SR Eddy</name></author><author><name sortKey="Krogh, A" uniqKey="Krogh A">A Krogh</name></author><author><name sortKey="Mitchison, G" uniqKey="Mitchison G">G Mitchison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rabiner, Lr" uniqKey="Rabiner L">LR Rabiner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frey, Bj" uniqKey="Frey B">BJ Frey</name></author><author><name sortKey="Mohammad, N" uniqKey="Mohammad N">N Mohammad</name></author><author><name sortKey="Morris, Qd" uniqKey="Morris Q">QD Morris</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Robinson, Md" uniqKey="Robinson M">MD Robinson</name></author><author><name sortKey="Mnaimneh, S" uniqKey="Mnaimneh S">S Mnaimneh</name></author><author><name sortKey="Chang, R" uniqKey="Chang R">R Chang</name></author><author><name sortKey="Pan, Q" uniqKey="Pan Q">Q Pan</name></author><author><name sortKey="Sat, E" uniqKey="Sat E">E Sat</name></author><author><name sortKey="Rossant, J" uniqKey="Rossant J">J Rossant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frey, Bj" uniqKey="Frey B">BJ Frey</name></author><author><name sortKey="Dueck, D" uniqKey="Dueck D">D Dueck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barash, Y" uniqKey="Barash Y">Y Barash</name></author><author><name sortKey="Calarco, Ja" uniqKey="Calarco J">JA Calarco</name></author><author><name sortKey="Gao, W" uniqKey="Gao W">W Gao</name></author><author><name sortKey="Pan, Q" uniqKey="Pan Q">Q Pan</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Shai, O" uniqKey="Shai O">O Shai</name></author><author><name sortKey="Blencowe, Bj" uniqKey="Blencowe B">BJ Blencowe</name></author><author><name sortKey="Frey, Bj" uniqKey="Frey B">BJ Frey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiss, Y" uniqKey="Weiss Y">Y Weiss</name></author><author><name sortKey="Freeman, Wt" uniqKey="Freeman W">WT Freeman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barber, D" uniqKey="Barber D">D Barber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mahony, S" uniqKey="Mahony S">S Mahony</name></author><author><name sortKey="Benos, Pv" uniqKey="Benos P">PV Benos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verrijzer, Cp" uniqKey="Verrijzer C">CP Verrijzer</name></author><author><name sortKey="Alkema, Mj" uniqKey="Alkema M">MJ Alkema</name></author><author><name sortKey="Van Weperen, Ww" uniqKey="Van Weperen W">WW van Weperen</name></author><author><name sortKey="Vanleeuwen, Hc" uniqKey="Vanleeuwen H">HC VanLeeuwen</name></author><author><name sortKey="Strating, Mj" uniqKey="Strating M">MJ Strating</name></author><author><name sortKey="Vander Vliet, Pc" uniqKey="Vander Vliet P">PC vander Vliet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gordan, R" uniqKey="Gordan R">R Gordan</name></author><author><name sortKey="Murphy, Kf" uniqKey="Murphy K">KF Murphy</name></author><author><name sortKey="Mccord, Rp" uniqKey="Mccord R">RP McCord</name></author><author><name sortKey="Zhu, C" uniqKey="Zhu C">C Zhu</name></author><author><name sortKey="Vedenko, A" uniqKey="Vedenko A">A Vedenko</name></author><author><name sortKey="Bulyk, Ml" uniqKey="Bulyk M">ML Bulyk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morris, Q" uniqKey="Morris Q">Q Morris</name></author><author><name sortKey="Bulyk, Ml" uniqKey="Bulyk M">ML Bulyk</name></author><author><name sortKey="Hughes, Tr" uniqKey="Hughes T">TR Hughes</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Californie</li><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Peng, Chengbin" sort="Peng, Chengbin" uniqKey="Peng C" first="Chengbin" last="Peng">Chengbin Peng</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Wong, Ka Chun" sort="Wong, Ka Chun" uniqKey="Wong K" first="Ka-Chun" last="Wong">Ka-Chun Wong</name></region><name sortKey="Li, Yue" sort="Li, Yue" uniqKey="Li Y" first="Yue" last="Li">Yue Li</name><name sortKey="Li, Yue" sort="Li, Yue" uniqKey="Li Y" first="Yue" last="Li">Yue Li</name><name sortKey="Wong, Ka Chun" sort="Wong, Ka Chun" uniqKey="Wong K" first="Ka-Chun" last="Wong">Ka-Chun Wong</name><name sortKey="Zhang, Zhaolei" sort="Zhang, Zhaolei" uniqKey="Zhang Z" first="Zhaolei" last="Zhang">Zhaolei Zhang</name><name sortKey="Zhang, Zhaolei" sort="Zhang, Zhaolei" uniqKey="Zhang Z" first="Zhaolei" last="Zhang">Zhaolei Zhang</name><name sortKey="Zhang, Zhaolei" sort="Zhang, Zhaolei" uniqKey="Zhang Z" first="Zhaolei" last="Zhang">Zhaolei Zhang</name><name sortKey="Zhang, Zhaolei" sort="Zhang, Zhaolei" uniqKey="Zhang Z" first="Zhaolei" last="Zhang">Zhaolei Zhang</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Chan, Tak Ming" sort="Chan, Tak Ming" uniqKey="Chan T" first="Tak-Ming" last="Chan">Tak-Ming Chan</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002024 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002024 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3763557
|texte= DNA motif elucidation using belief propagation
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23814189" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |